mTORC1 supports progression toward activation competence in quiescent adult neural stem cells

Thetiot M, Bally-Cuif L et al. · 2026 · bioRxiv · Atlas ID THE2026

What this study shows

In the adult zebrafish brain, mTORC1 activity is enriched during a long quiescence phase in which neural stem cells become able to activate; perturbing mTORC1 changes how cells progress through this phase, setting the tempo of the move towards activation while preserving stemness. Preprint, not peer-reviewed.

Abstract

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Neural stem cells (NSCs) sustain lifelong neurogenesis through the tight regulation of quiescence, self-renewal and differentiation. Quiescent NSCs (qNSCs) exist in distinct substates, ranging from deep to shallow quiescence, yet the mechanisms governing these transitions remain unclear. In long-term self-renewing NSCs of the adult zebrafish pallium, we show that mTORC1 activity is specifically enriched during a prolonged quiescence phase in which NSCs acquire activation competence.

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At a glance

Evidence type	PP Preprint, not peer-reviewed This is a preprint, not yet peer-reviewed -- treat its findings as provisional until formal publication. Preprints carry their own marker because peer-review status is a different question from which system was studied.
Study type	Preprint
Model system	Adult zebrafish pallium neural stem cells; in situ analysis and single-cell RNA-seq
Journal	bioRxiv
Year	2026
Peer reviewed	No
Record last updated	2026-09-23
Source	DOI 10.64898/2026.05.04.722648

Extracted findings

Intervention	Functional mTORC1 perturbation in vivo
Target	mTORC1 in quiescent neural stem cells
Model	Zebrafish
Effect	mTORC1 sets the tempo of quiescent neural stem cells' progression toward activation

Cite this paper

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Thetiot, M., et al. (2026). mTORC1 supports progression toward activation competence in quiescent adult neural stem cells. bioRxiv. https://doi.org/10.64898/2026.05.04.722648

@article{THE2026,
  author       = {Thetiot, M. and Bally-Cuif, L. and others},
  title        = {{mTORC1 supports progression toward activation competence in quiescent adult neural stem cells}},
  journal      = {bioRxiv},
  year         = {2026},
  doi          = {10.64898/2026.05.04.722648},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record THE2026) [Data set]. https://mtor-atlas.org/study/THE2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_THE2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record THE2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/THE2026/},
  doi          = {10.5281/zenodo.22059963}
}