mTORC1 supports progression toward activation competence in quiescent adult neural stem cells
What this study shows
In the adult zebrafish brain, mTORC1 activity is enriched during a long quiescence phase in which neural stem cells become able to activate; perturbing mTORC1 changes how cells progress through this phase, setting the tempo of the move towards activation while preserving stemness. Preprint, not peer-reviewed.
Abstract
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Neural stem cells (NSCs) sustain lifelong neurogenesis through the tight regulation of quiescence, self-renewal and differentiation. Quiescent NSCs (qNSCs) exist in distinct substates, ranging from deep to shallow quiescence, yet the mechanisms governing these transitions remain unclear. In long-term self-renewing NSCs of the adult zebrafish pallium, we show that mTORC1 activity is specifically enriched during a prolonged quiescence phase in which NSCs acquire activation competence.
Read the full abstract →At a glance
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| Evidence type | PP Preprint, not peer-reviewed This is a preprint, not yet peer-reviewed -- treat its findings as provisional until formal publication. Preprints carry their own marker because peer-review status is a different question from which system was studied. |
| Study type | Preprint |
| Model system | Adult zebrafish pallium neural stem cells; in situ analysis and single-cell RNA-seq |
| Journal | bioRxiv |
| Year | 2026 |
| Peer reviewed | No |
| Record last updated | 2026-10-01 |
| Source | DOI 10.64898/2026.05.04.722648 |
Where this study fits
How this study connects to the pathway map, open questions, people and other studies in the Atlas.
People in the Atlas
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Studies how adult neural stem cells in the zebrafish brain move between dormancy and activation
More: 4 other authors
No profile yet: Thetiot M, Taing L, Morizet D, Letort G
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Extracted findings
These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.
| Intervention | Functional mTORC1 perturbation in vivo |
| Target | mTORC1 in quiescent neural stem cells |
| Model | Zebrafish |
| Effect | mTORC1 sets the tempo of quiescent neural stem cells' progression toward activation |
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