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Rapamycin-induced fatty liver in mice is attenuated by chloroquine co-treatment in an ERRα-dependent manner

B'chir W, Giguère V et al. · 2026 · Journal of Endocrinology · Atlas ID BCH2026

What this study shows

Chloroquine co-treatment attenuates rapamycin-induced hepatic steatosis (a known mTORC1-inhibitor side effect) in mice, and this rescue depends on the nuclear receptor ERRα; RNA-seq shows chloroquine reverses rapamycin-driven upregulation of lipid-metabolism genes, with ERRα identified as a top transcriptional regulator of the effect.

Abstract

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Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), remains a major health concern world-wide. Hepatic steatosis manifests by the aberrant accumulation of lipids in hepatocytes. We have previously shown that pharmacological inhibition of mTOR complex 1 (mTORC1) by rapamycin, a widely utilized potent immunosuppressant, induces MASLD under normal conditions.

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At a glance

Evidence type A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse (rapamycin-induced MASLD model; ERRα-null mice)); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type4 - Animal Study
Model systemMouse (rapamycin-induced MASLD model; ERRα-null mice)
JournalJournal of Endocrinology
Year2026
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1530/JOE-26-0176 · PMID 42544714

Extracted findings

InterventionChloroquine co-treatment with rapamycin
TargetERRα (Esrra) / mTORC1
ModelMouse
EffectChloroquine co-treatment attenuates rapamycin-induced hepatic steatosis in an ERRα-dependent manner

In the Atlas

Related topics

RapamycinmTORC1

More studies on this topic

Cite this paper

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B'chir, W., et al. (2026). Rapamycin-induced fatty liver in mice is attenuated by chloroquine co-treatment in an ERRα-dependent manner. Journal of Endocrinology. https://doi.org/10.1530/JOE-26-0176

@article{BCH2026,
  author       = {B'chir, W. and Giguère, V. and others},
  title        = {{Rapamycin-induced fatty liver in mice is attenuated by chloroquine co-treatment in an ERRα-dependent manner}},
  journal      = {Journal of Endocrinology},
  year         = {2026},
  doi          = {10.1530/JOE-26-0176},
  note         = {PMID: 42544714},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record BCH2026) [Data set]. https://mtor-atlas.org/study/BCH2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BCH2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BCH2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BCH2026/},
  doi          = {10.5281/zenodo.22059963}
}