Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress response

Anabolic and catabolic processes are coordinated by a conserved regulatory network including mTORC1 and FoxO. Spalt-related (Salr), previously implicated in organogenesis, is identified as a negative regulator of growth and lipid storage in Drosophila. Salr activates catabolic gene expression and restricts mTORC1-mediated cell growth in the fat body. Salr is activated in a slow and sustained manner through the integrated stress response, distinct from transient FoxO activation. Once activated, Salr counters nuclear localization of FoxO.

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Onur Deniz, Ying Liu, Tuuli Kirkinen, Krista Kokki, Kateryna Gaertner, Pau Clavell-Revelles, Jaakko Mattila, & Ville Hietakangas (2026). Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress response. The EMBO Journal. https://doi.org/10.1038/s44318-026-00858-1

@article{DEN2026,
  author       = {Onur Deniz and Ying Liu and Tuuli Kirkinen and Krista Kokki and Kateryna Gaertner and Pau Clavell-Revelles and Jaakko Mattila and Ville Hietakangas},
  title        = {{Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress response}},
  journal      = {The EMBO Journal},
  year         = {2026},
  doi          = {10.1038/s44318-026-00858-1},
  note         = {PMID: 42436355},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DEN2026) [Data set]. https://mtor-atlas.org/study/DEN2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DEN2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DEN2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DEN2026/},
  doi          = {10.5281/zenodo.22059963}
}