Spalt-related (Salr)
Transcription factor in Drosophila identified as a novel inhibitor of mTORC1-mediated growth, activated by the integrated stress response to restrict anabolic processes during nutrient stress.
A fly-only relay in this map. A gene switch found in fruit flies that blocks mTORC1-driven growth. It's turned on by the cell's stress-alarm system to slow down growth-related processes when nutrients are scarce.
No established mammalian orthologue in this role; kept visible so the fly-derived longevity evidence is not silently generalised.
TL;DR. Spalt-related (Salr) appears in 1 curated study in Oliver's mTOR Atlas: 1 in animal models. No study in people is recorded for it in the Atlas yet. It has 2 interactions in the curated pathway model.
In the pathway model
| Interaction | Mechanism | Evidence | Studies |
|---|---|---|---|
| Spalt-related (Salr) inhibits mTORC1 mechanism: signal-relay · this link in full · on the map table | This stress-induced protein suppresses mTORC1-driven growth once stress signalling turns it on. Salr suppresses mTORC1-driven growth downstream of stress signalling. Salr suppresses mTORC1-driven growth downstream of stress signalling. Holds under: One Drosophila study (DEN2026). Fly only and a single study; no mammalian or human data are cited for this edge. not tested in people · emerging, few independent studies | A | DEN2026 |
| Integrated stress response activates Spalt-related (Salr) mechanism: transcriptional · this link in full · on the map table | The cell's stress-response system switches on a growth-blocking gene – a route to shutting down mTORC1 that skips right past TSC and AMPK. The integrated stress response switches on Salr, a growth inhibitor - a route into mTORC1 that bypasses TSC and AMPK entirely. The integrated stress response switches on Salr, a growth inhibitor - a route into mTORC1 that bypasses TSC and AMPK entirely. Holds under: Fly only, and newly reported. not tested in people · emerging, few independent studies | A | DEN2026 |
Evidence at a glance
| Evidence | What it means | Studies |
|---|---|---|
| A | Animal model | 1 |
No direct human evidence in the Atlas for this entity yet — everything below rests on animal or molecular work.
Studies
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress response DEN2026 Transcription factor Spalt-related (Salr) is a novel mTORC1 inhibitor in Drosophila activated by the integrated stress response, restricting anabolic growth and lipid storage during nutrient stress. Salr responds to a distinct, ISR-driven cue, acting convergently with FoxO rather than downstream of it. |
Related entities
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