Oliver's mTOR Atlas Evidence Platform
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Pathway link SALR-MTORC1

Spalt-related (Salr) mTORC1

Spalt-related (Salr) inhibits mTORC1.

This stress-induced protein suppresses mTORC1-driven growth once stress signalling turns it on.

Salr suppresses mTORC1-driven growth downstream of stress signalling.

The conditions it holds under

One Drosophila study (DEN2026). Fly only and a single study; no mammalian or human data are cited for this edge.

Time it takes
hours
Step
not yet resolved
Measured in
fly
Where in the cell
cytosol
Reaches people?
not tested in people
How settled
emerging, few independent studies

Studies behind it

YearEvidenceStudy
2026 A Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress responseDEN2026 Transcription factor Spalt-related (Salr) is a novel mTORC1 inhibitor in Drosophila activated by the integrated stress response, restricting anabolic growth and lipid storage during nutrient stress. Salr responds to a distinct, ISR-driven cue, acting convergently with FoxO rather than downstream of it.

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by
No researcher outside the project has checked this link yet.
Curator sign-off
Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
Curated by
Oliver Barton, with AI help for drafting; see how links are checked.

“Inhibits” describes the effect on the target's activity, not on how much of it there is.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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