Pathway link ISR-SALR
Integrated stress response Spalt-related (Salr)
Integrated stress response activates Spalt-related (Salr).
The cell's stress-response system switches on a growth-blocking gene – a route to shutting down mTORC1 that skips right past TSC and AMPK.
The conditions it holds under
Fly only, and newly reported.
- Time it takes
- hours
- Step
- indirect (through steps not drawn here)
- Measured in
- fly
- Where in the cell
- nucleus
- Reaches people?
- not tested in people
- How settled
- emerging, few independent studies
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress responseDEN2026 Transcription factor Spalt-related (Salr) is a novel mTORC1 inhibitor in Drosophila activated by the integrated stress response, restricting anabolic growth and lipid storage during nutrient stress. Salr responds to a distinct, ISR-driven cue, acting convergently with FoxO rather than downstream of it. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
← The whole pathway · This link as JSON
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