{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "ISR-SALR",
  "claim": "Integrated stress response activates Spalt-related (Salr)",
  "source": {
   "name": "Integrated stress response",
   "entity": "integrated-stress-response"
  },
  "target": {
   "name": "Spalt-related (Salr)",
   "entity": "spalt-related-salr"
  },
  "effect": "activates",
  "type": "transcriptional",
  "directness": "indirect",
  "timescale": "hours",
  "compartment": "nucleus",
  "map_band": "nucleus",
  "species": [
   "fly"
  ],
  "mechanism": "The integrated stress response switches on Salr, a growth inhibitor - a route into mTORC1 that bypasses TSC and AMPK entirely.",
  "mechanism_beginner": "The cell's stress-response system switches on a growth-blocking gene – a route to shutting down mTORC1 that skips right past TSC and AMPK.",
  "context": null,
  "boundary": "Fly only, and newly reported.",
  "note": "Thin and species-limited, but it is a genuinely different input route - worth showing as such.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "untested",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "DEN2026"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/ISR-SALR/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/ISR-SALR.json"
 }
}