Molecular switches of SQSTM1: the impact of post-translational modifications on autophagy and neurodegeneration

Abrar F, Martin DDO · 2026 · Autophagy · Atlas ID ABR2026

What this study shows

Comprehensive review of how post-translational modifications (phosphorylation, ubiquitination, acetylation, S-acylation, S-nitrosylation) tune SQSTM1/p62's role as the autophagy cargo-receptor hub -- relevant to neurodegenerative disease (Alzheimer's, ALS, Huntington's) where SQSTM1 regulation goes awry.

Abstract

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SQSTM1/p62 (sequestosome 1) is an important receptor protein involved in many cellular signaling processes, including macroautophagy/autophagy. It is a molecular hub for cellular homeostasis and cellular responses. Within autophagy, SQSTM1 targets ubiquitinated cargo for degradation, maintaining cellular proteostasis. Structurally, SQSTM1 consists of several domains that facilitate its binding to ubiquitinated cargo, the formation of SQSTM1 aggregate inclusions, interactions with MAP1LC3/LC3, and the mediation of clearance via the autophagy pathway.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Autophagy
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1080/15548627.2026.2711593 · PMID 42560011

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	none (review)
Target	SQSTM1/p62 / MTORC1 / autophagy
Model	Review
Effect	Summarises how PTMs of SQSTM1 tune its autophagy-receptor function and its regulation of and by MTORC1.

In the Atlas

Cite this paper

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Abrar, F., & Martin, D. D. O. (2026). Molecular switches of SQSTM1: the impact of post-translational modifications on autophagy and neurodegeneration. Autophagy. https://doi.org/10.1080/15548627.2026.2711593

@article{ABR2026,
  author       = {Abrar, F. and Martin, D. D. O.},
  title        = {{Molecular switches of SQSTM1: the impact of post-translational modifications on autophagy and neurodegeneration}},
  journal      = {Autophagy},
  year         = {2026},
  doi          = {10.1080/15548627.2026.2711593},
  note         = {PMID: 42560011},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ABR2026) [Data set]. https://mtor-atlas.org/study/ABR2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ABR2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ABR2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ABR2026/},
  doi          = {10.5281/zenodo.22059963}
}

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