Testosterone propionate maintains autophagic flux and mitochondrial integrity via regulation of the LC3B/p62/Beclin-1/mTOR axis in induced liver fibrosis.

Verma S, Vaishnav S, Yadav M, Verma S, Washimkar KR, Kumar A, Mugale MN · 2026 · Journal of Molecular Histology · Atlas ID VER2026

What this study shows

Testosterone propionate protects against CCl4-induced liver fibrosis by maintaining mTOR-regulated autophagic flux via the LC3B/p62/Beclin-1 axis, preserving mitochondrial integrity; castration worsens fibrosis by impairing this pathway.

Abstract

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In a CCl4-induced chronic liver injury rat model, testosterone propionate was found to preserve autophagic flux and mitochondrial function. Androgen deprivation worsened hepatic damage, while testosterone treatment maintained the LC3B/p62/Beclin-1/mTOR axis and protected mitochondrial quality control and reduced apoptosis.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Rat); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Rat
Journal	Journal of Molecular Histology
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1007/s10735-026-10905-0 · PMID 42461311

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Testosterone propionate
Target	mTOR / LC3B / p62 / Beclin-1 autophagy axis
Model	Rat
Effect	Testosterone maintains mTOR-regulated autophagy and mitochondrial integrity; androgen deprivation impairs autophagy and worsens liver fibrosis

In the Atlas

Cite this paper

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Verma, S., Vaishnav, S., Yadav, M., Verma, S., Washimkar, K. R., Kumar, A., & Mugale, M. N. (2026). Testosterone propionate maintains autophagic flux and mitochondrial integrity via regulation of the LC3B/p62/Beclin-1/mTOR axis in induced liver fibrosis. Journal of Molecular Histology. https://doi.org/10.1007/s10735-026-10905-0

@article{VER2026,
  author       = {Verma, S. and Vaishnav, S. and Yadav, M. and Verma, S. and Washimkar, K. R. and Kumar, A. and Mugale, M. N.},
  title        = {{Testosterone propionate maintains autophagic flux and mitochondrial integrity via regulation of the LC3B/p62/Beclin-1/mTOR axis in induced liver fibrosis}},
  journal      = {Journal of Molecular Histology},
  year         = {2026},
  doi          = {10.1007/s10735-026-10905-0},
  note         = {PMID: 42461311},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record VER2026) [Data set]. https://mtor-atlas.org/study/VER2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_VER2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record VER2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/VER2026/},
  doi          = {10.5281/zenodo.22059963}
}

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