Autophagy cargo receptor and mTORC1-activating scaffold on lysosomes; elevated p62 accumulation indicates impaired autophagic flux.
| Tier | What it means | Studies |
|---|---|---|
| C | Animal in vivo | 2 |
| D | Mechanistic / in vitro / review | 1 |
No direct human evidence in the Atlas for this entity yet — everything below rests on animal or mechanistic work.
| Study | Year | Tier | Finding |
|---|---|---|---|
| MA2026 | 2026 | C | PIP4K2A overexpression attenuates cerebral ischemia/reperfusion injury by reducing TRIB3-p62 complex burden and modulating AKT/mTOR signaling to restore autophagic flux, identifying PIP4K2A-AKT/mTOR a |
| VER2026 | 2026 | C | Testosterone propionate protects against CCl4-induced liver fibrosis by maintaining mTOR-regulated autophagic flux via the LC3B/p62/Beclin-1 axis, preserving mitochondrial integrity; castration worsen |
| ULL2026 | 2026 | D | In BHD patient-derived kidney cancer cells, FLCN loss causes constitutive nuclear TFEB localization and mTORC1 hyperactivation, but leaves bulk autophagy flux and LC3 lipidation unaffected; however, t |