Beclin-1 (BECN1)

Gene/Protein · 3 studies in the Atlas

Core autophagy protein required for autophagosome nucleation; regulated by mTOR and inhibited by Bcl-2 family members.

A core protein required to start building autophagosomes, the sacs that carry out cellular cleanup. It's controlled by mTOR and held back by the Bcl-2 family of proteins.

Core autophagy protein required for autophagosome nucleation; regulated by mTOR and inhibited by Bcl-2 family members.

TL;DR. Beclin-1 (BECN1) appears in 3 curated studies in Oliver's mTOR Atlas: 3 in animal models. No study in people is recorded for it in the Atlas yet.

Evidence at a glance

Evidence	What it means	Studies
A	Animal model	3

No direct human evidence in the Atlas for this entity yet — everything below rests on animal or molecular work.

Studies

Year	Evidence	Study
2026	A	Testosterone propionate maintains autophagic flux and mitochondrial integrity via regulation of the LC3B/p62/Beclin-1/mTOR axis in induced liver fibrosis. VER2026 Testosterone propionate protects against CCl4-induced liver fibrosis by maintaining mTOR-regulated autophagic flux via the LC3B/p62/Beclin-1 axis, preserving mitochondrial integrity; castration worsens fibrosis by impairing this pathway.
2026	A	Role of Autophagy in Scleral Remodeling During Form-Deprivation Myopia WEN2026 Excess scleral autophagy links hypoxic stress to extracellular matrix remodelling in experimental myopia. In form-deprived guinea pigs, subconjunctival rapamycin made myopia worse and 3-MA alleviated it, while atropine slowed myopia and suppressed autophagy-related changes. AMPK/mTOR/P70S6K signalling was measured, but the paper does not establish it as the mediating route.
2026	A	Dioscorea polystachya Turcz. attenuates male reproductive aging through modulation of mTOR-Beclin-1-mediated autophagy in Leydig and Sertoli cells ZHANG2026B Chinese yam protein extract (CYCSE) attenuates male reproductive aging by activating testicular autophagy through the mTOR-Beclin-1 axis in Leydig and Sertoli cells; mTOR activation blocks protective effects.

Related entities

Autophagy 3 mTOR 2 Rapamycin 1LC3B (MAP1LC3B)p62/SQSTM1 1 Cellular senescence 1 Hypoxia 1

Cite this page

ShowHide

Barton, O. (2026). Beclin-1 (BECN1) [Entity page]. In Oliver's mTOR Atlas [Data set]. https://mtor-atlas.org/gene/beclin-1-becn1/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_gene_beclin_1_becn1,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}: Beclin-1 (BECN1)},
  howpublished = {Entity page in a data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/gene/beclin-1-becn1/},
  doi          = {10.5281/zenodo.22059963}
}

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