Role of Autophagy in Scleral Remodeling During Form-Deprivation Myopia

Autophagy has been implicated in tissue remodeling, but its role in scleral remodeling during myopia development and in atropine-mediated myopia control remains unclear. Human scleral fibroblasts exposed to hypoxia were treated with rapamycin (RAPA) or 3-methyladenine (3-MA). In vivo, form-deprivation myopia (FDM) was induced in guinea pigs, followed by atropine, RAPA, or 3-MA intervention. Hypoxia induced scleral fibroblast remodeling; 3-MA attenuated these changes, whereas RAPA aggravated them. In FDM guinea pigs, atropine slowed myopia progression and suppressed autophagy-related changes.

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Wen, J., Tang, S., & Zhang Xiaoxiao (2026). Role of Autophagy in Scleral Remodeling During Form-Deprivation Myopia. FASEB Journal. https://doi.org/10.1096/fj.202600954RR

@article{WEN2026,
  author       = {Wen, J. and Tang, S. and Zhang Xiaoxiao},
  title        = {{Role of Autophagy in Scleral Remodeling During Form-Deprivation Myopia}},
  journal      = {FASEB Journal},
  year         = {2026},
  doi          = {10.1096/fj.202600954RR},
  note         = {PMID: 42545197},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WEN2026) [Data set]. https://mtor-atlas.org/study/WEN2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WEN2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WEN2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WEN2026/},
  doi          = {10.5281/zenodo.22059963}
}