Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Mammalian target of rapamycin (mTOR) is a central regulator of protein synthesis whose activity is modulated by a variety of signals. Energy depletion and hypoxia result in mTOR inhibition. While energy depletion inhibits mTOR through a process involving the activation of AMP-activated protein kinase (AMPK) by LKB1 and subsequent phosphorylation of TSC2, the mechanism of mTOR inhibition by hypoxia is not known. Here we show that mTOR inhibition by hypoxia requires the TSC1/TSC2 tumor suppressor complex and the hypoxia-inducible gene REDD1/RTP801.

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Brugarolas, J., et al. (2004). Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes & development. https://doi.org/10.1101/gad.1256804

@article{BRU2004,
  author       = {Brugarolas, J. and Kaelin, W. G. and others},
  title        = {{Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex}},
  journal      = {Genes & development},
  year         = {2004},
  doi          = {10.1101/gad.1256804},
  note         = {PMID: 15545625},
}

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Barton, O. (2026). Oliver's mTOR Atlas (record BRU2004) [Data set]. https://mtor-atlas.org/study/BRU2004/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BRU2004,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BRU2004},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BRU2004/},
  doi          = {10.5281/zenodo.22059963}
}