Pathway link REDD1-TSC

REDD1 (DDIT4) → TSC1/TSC2

REDD1 (DDIT4) activates TSC1/TSC2.

REDD1 acts through the TSC brake, so low oxygen and low growth-factor signals end up hitting the very same switch.

REDD1 works through the TSC complex, not around it - hypoxia and growth factors therefore converge on the same brake.

The conditions it holds under

One study in mammalian cells (BRU2004). A single study, not replicated in this corpus, and not tested in whole animals or in people.

Time it takes

hours

Step

indirect (through steps not drawn here)

Measured in

mammalian cells

Where in the cell

cytosol

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

← The whole pathway · This link as JSON