{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "REDD1-TSC",
  "claim": "REDD1 (DDIT4) activates TSC1/TSC2",
  "source": {
   "name": "REDD1 (DDIT4)",
   "entity": "redd1-ddit4"
  },
  "target": {
   "name": "TSC1/TSC2",
   "entity": "tsc1-tsc2"
  },
  "effect": "activates",
  "type": "signal-relay",
  "directness": "indirect",
  "timescale": "hours",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "REDD1 works through the TSC complex, not around it - hypoxia and growth factors therefore converge on the same brake.",
  "mechanism_beginner": "REDD1 acts through the TSC brake, so low oxygen and low growth-factor signals end up hitting the very same switch.",
  "context": null,
  "boundary": "One study in mammalian cells (BRU2004). A single study, not replicated in this corpus, and not tested in whole animals or in people.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "BRU2004"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/REDD1-TSC/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/REDD1-TSC.json"
 }
}