Pathway link HYPOXIA-REDD1

Hypoxia → REDD1 (DDIT4)

Hypoxia activates REDD1 (DDIT4).

Low oxygen switches on the gene for REDD1 over hours - slower than AMPK. REDD1 protein is short-lived, so the signal lasts only while low oxygen keeps the gene on.

Low oxygen induces REDD1 transcriptionally over hours, slower than AMPK. REDD1 protein is short-lived, so the signal lasts only as long as hypoxia keeps the gene switched on.

The conditions it holds under

Single-study edge in this corpus.

Time it takes

hours

Step

indirect (through steps not drawn here)

Measured in

mammalian cells

Where in the cell

nucleus

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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