PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling.

Ma B, Yu X, Li M, Zhu H, Dong X, Yu S, Wang M, Wu G, Wang X, Hu R, Feng H · 2026 · Translational stroke research · Atlas ID MA2026

What this study shows

PIP4K2A overexpression attenuates cerebral ischemia/reperfusion injury by reducing TRIB3-p62 complex burden and modulating AKT/mTOR signaling to restore autophagic flux, identifying PIP4K2A-AKT/mTOR as a neuroprotective axis in stroke.

Abstract

ShowHide

Ischemic stroke is the most prevalent form of stroke worldwide and remains a major cause of long-term disability. Impaired autophagic flux is a critical pathological mechanism that worsens neuronal injury after ischemia. This study aimed to elucidate the role of phosphatidylinositol-5-phosphate 4-kinase type II alpha (PIP4K2A) and its regulation of autophagy in cerebral ischemia/reperfusion (I/R) injury. Exploratory TMT-based serum proteomics identified PIP4K2A as an elevated candidate protein in patients with acute ischemic stroke (AIS).

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse
Journal	Translational stroke research
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1007/s12975-026-01474-1 · PMID 42467322

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	PIP4K2A overexpression
Target	AKT/mTOR / autophagy / TRIB3-p62
Model	Mouse
Effect	PIP4K2A restored autophagic flux and reduced neuronal injury via AKT/mTOR modulation in I/R stroke

In the Atlas

Cite this paper

ShowHide

Ma, B., Yu, X., Li, M., Zhu, H., Dong, X., Yu, S., Wang, M., Wu, G., Wang, X., Hu, R., & Feng, H. (2026). PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling. Translational stroke research. https://doi.org/10.1007/s12975-026-01474-1

@article{MA2026,
  author       = {Ma, B. and Yu, X. and Li, M. and Zhu, H. and Dong, X. and Yu, S. and Wang, M. and Wu, G. and Wang, X. and Hu, R. and Feng, H.},
  title        = {{PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling}},
  journal      = {Translational stroke research},
  year         = {2026},
  doi          = {10.1007/s12975-026-01474-1},
  note         = {PMID: 42467322},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MA2026) [Data set]. https://mtor-atlas.org/study/MA2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MA2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MA2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MA2026/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?