PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling.

Ma B, Yu X, Li M, Zhu H, Dong X, Yu S et al. · 2026 · Translational stroke research · Atlas ID MA2026

What this study shows

PIP4K2A overexpression attenuates cerebral ischemia/reperfusion injury by reducing TRIB3-p62 complex burden and modulating AKT/mTOR signaling to restore autophagic flux, identifying PIP4K2A-AKT/mTOR as a neuroprotective axis in stroke.

Abstract

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Ischemic stroke remains a major cause of long-term disability. Impaired autophagic flux worsens neuronal injury after ischemia. This study elucidates the role of PIP4K2A and its regulation of autophagy in cerebral ischemia/reperfusion (I/R) injury using serum proteomics and in vivo stroke models.

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At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse
Journal	Translational stroke research
Year	2026
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1007/s12975-026-01474-1

Extracted findings

Intervention	PIP4K2A overexpression
Target	AKT/mTOR / autophagy / TRIB3-p62
Model	Mouse
Effect	PIP4K2A restored autophagic flux and reduced neuronal injury via AKT/mTOR modulation in I/R stroke

In the Atlas

Cite this paper

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Ma, B., et al. (2026). PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling. Translational stroke research. https://doi.org/10.1007/s12975-026-01474-1

@article{MA2026,
  author       = {Ma, B. and Yu, X. and Li, M. and Zhu, H. and Dong, X. and Yu, S. and others},
  title        = {{PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling}},
  journal      = {Translational stroke research},
  year         = {2026},
  doi          = {10.1007/s12975-026-01474-1},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MA2026) [Data set]. https://mtor-atlas.org/study/MA2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MA2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MA2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MA2026/},
  doi          = {10.5281/zenodo.22059963}
}