Molecular and metabolic dysregulation of lung cancer in developing anti-tumor activity by gambogic acid mediated mTOR signaling: in vitro and computational study.

Bo S, Liao Y, Chen X, Liu L, Pang F, Zhou L · 2026 · 3 Biotech · Atlas ID BO2026

What this study shows

Computational (network pharmacology and docking) plus in vitro study: gambogic acid is cytotoxic and pro-apoptotic in A549 lung cancer cells and docks most strongly to AKT and the mTOR effector S6K1 (RPS6KB1). Direct mTOR kinase inhibition was not measured; no in vivo or human data.

Abstract

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Gambogic acid (GA), a natural xanthonoid compound, was investigated for its anticancer activity in lung cancer via mTOR signaling inhibition using computational and in vitro approaches. GA demonstrated high lipophilicity and docking interactions with mTOR pathway components, resulting in anti-proliferative and pro-apoptotic effects in lung cancer cell lines.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Human lung cancer cell lines) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Human lung cancer cell lines
Journal	3 Biotech
Year	2026
Peer reviewed	Yes
Record last updated	2026-07-29
Source	DOI 10.1007/s13205-026-04938-1 · PMID 42459409 · Free full text (PMC13369087)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Gambogic acid
Target	mTOR signaling pathway
Model	Human (cell line)
Effect	Cytotoxic and pro-apoptotic in lung cancer cells; docking implicates the AKT-S6K1 (RPS6KB1) axis; mTOR inhibition not directly measured

In the Atlas

Cite this paper

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Bo, S., Liao, Y., Chen, X., Liu, L., Pang, F., & Zhou, L. (2026). Molecular and metabolic dysregulation of lung cancer in developing anti-tumor activity by gambogic acid mediated mTOR signaling: in vitro and computational study. 3 Biotech. https://doi.org/10.1007/s13205-026-04938-1

@article{BO2026,
  author       = {Bo, S. and Liao, Y. and Chen, X. and Liu, L. and Pang, F. and Zhou, L.},
  title        = {{Molecular and metabolic dysregulation of lung cancer in developing anti-tumor activity by gambogic acid mediated mTOR signaling: in vitro and computational study}},
  journal      = {3 Biotech},
  year         = {2026},
  doi          = {10.1007/s13205-026-04938-1},
  note         = {PMID: 42459409},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BO2026) [Data set]. https://mtor-atlas.org/study/BO2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BO2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BO2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BO2026/},
  doi          = {10.5281/zenodo.22059963}
}

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