Dale D. O. Martin
Studies protein mislocalization and disturbed protein recycling (proteostasis) in Huntington disease and ALS.
Associate Professor and Program Director, Medical and Biomedical Sciences, Department of Biology, University of Waterloo · PhD, University of Alberta (2011)
NeurdyPhagy Lab, Department of Biology, University of Waterloo (Waterloo, Ontario, Canada) ↗
Dale Martin leads a group at the University of Waterloo that studies how proteins end up in the wrong place in brain cells and how that damages them, with a focus on Huntington disease and ALS. The lab also works on getting drugs across the blood-brain barrier.
The 2026 review in the Atlas, written with Fatima Abrar, covers SQSTM1, also called p62. This protein marks damaged or unwanted material for autophagy, the cell's recycling process, which mTORC1 helps to restrain. The review describes how chemical tags on SQSTM1, such as phosphate, ubiquitin and fatty acid groups, change where it sits and what it does.
Understanding these switches may help explain why autophagy fails in neurodegenerative diseases and where treatments could act.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | R | Molecular switches of SQSTM1: the impact of post-translational modifications on autophagy and neurodegeneration ABR2026 Senior author of a review on how post-translational modifications of SQSTM1/p62 control autophagy and relate to neurodegeneration. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Dale D. O. Martin.
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- Fatima Abrar First author of a 2026 review on how chemical tags on the autophagy receptor SQSTM1/p62 are linked to neurodegenerative disease
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