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mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-cell precursor acute lymphoblastic leukemia

Dąbkowska A, Janowska M, Pastorczak A, Domka K, Nowicka Z, Urbanska Z, Zając W, Bugajewski M, Grzybowska J, Pruchniak P, Fidyt K, Fendler W · 2026 · Leukemia · Atlas ID DAB2026

What this study shows

mTORC1 inhibitors upregulate CD20 via the AKT-FOXO1 axis and promote B-lineage maturation in B-cell precursor ALL, enhancing the antitumor efficacy of anti-CD20 monoclonal antibodies -- including in high-risk IKZF1-deleted disease -- providing a rationale for combining mTORC1 inhibition with CD20-directed immunotherapy.

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: BCP-ALL cell lines; patient-derived and in vivo models) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemBCP-ALL cell lines; patient-derived and in vivo models
JournalLeukemia
Year2026
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1038/s41375-026-03093-z · PMID 42618701

In the Atlas

Related topics

FoxOmTORC1

More studies on this topic

Cite this paper

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Dąbkowska, A., Janowska, M., Pastorczak, A., Domka, K., Nowicka, Z., Urbanska, Z., Zając, W., Bugajewski, M., Grzybowska, J., Pruchniak, P., Fidyt, K., Fendler, W., Taslim, J., Crump, N. T., Ushmorov, A., Patkowska, E., & Firczuk, M. (2026). mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-cell precursor acute lymphoblastic leukemia. Leukemia. https://doi.org/10.1038/s41375-026-03093-z

@article{DAB2026,
  author       = {Dąbkowska, A. and Janowska, M. and Pastorczak, A. and Domka, K. and Nowicka, Z. and Urbanska, Z. and Zając, W. and Bugajewski, M. and Grzybowska, J. and Pruchniak, P. and Fidyt, K. and Fendler, W. and Taslim, J. and Crump, N. T. and Ushmorov, A. and Patkowska, E. and Firczuk, M.},
  title        = {{mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-cell precursor acute lymphoblastic leukemia}},
  journal      = {Leukemia},
  year         = {2026},
  doi          = {10.1038/s41375-026-03093-z},
  note         = {PMID: 42618701},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record DAB2026) [Data set]. https://mtor-atlas.org/study/DAB2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DAB2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DAB2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DAB2026/},
  doi          = {10.5281/zenodo.22059963}
}