Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides)

Tao J, Chen S, Liu N, Gong Y, Zhang S, He J, Huang X, Chen N, Li S · 2026 · FASEB Journal · Atlas ID TAO2026

What this study shows

mTOR/SREBP1 signaling governs hepatic glucose partitioning; the insulin-responsive mTOR/SREBP1 axis promotes lipogenesis versus glycogen accumulation. In this model -- a carnivorous fish -- impairment of the axis is associated with hepatic glycogen overload mimicking glucose intolerance.

Abstract

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Hepatic glycogen accumulation is a hallmark of glucose intolerance in carnivorous fish, yet the molecular mechanisms governing the partitioning of surplus carbohydrates remain poorly understood. This study integrated physiology and functional assays to elucidate how insulin-dependent mTOR/SREBP1 signaling governs hepatic glucose partitioning and glycogen accumulation. In the present study, we used largemouth bass (poor glucose utilization) and Nile tilapia (efficient glucose utilization) fed diets containing graded carbohydrate levels for 8 weeks.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Carnivorous fish (hepatic glycogen accumulation model)); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Carnivorous fish (hepatic glycogen accumulation model)
Journal	FASEB Journal
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1096/fj.202602519R · PMID 42606523

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	graded dietary carbohydrate; insulin treatment; rapamycin; srebp1, akt1, s6k1 and tsc2 knockdown in primary hepatocytes
Target	insulin / PI3K-AKT1-mTOR / SREBP1 lipogenic axis
Model	fish (largemouth bass Micropterus salmoides and Nile tilapia), in vivo and primary hepatocytes
Effect	High-carbohydrate diets suppressed the AKT1/mTOR/SREBP1 axis in largemouth bass and caused hepatic glycogen overload, while insulin restored the axis and shifted partitioning back toward lipogenesis.

In the Atlas

Cite this paper

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Tao, J., Chen, S., Liu, N., Gong, Y., Zhang, S., He, J., Huang, X., Chen, N., & Li, S. (2026). Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides). FASEB Journal. https://doi.org/10.1096/fj.202602519R

@article{TAO2026,
  author       = {Tao, J. and Chen, S. and Liu, N. and Gong, Y. and Zhang, S. and He, J. and Huang, X. and Chen, N. and Li, S.},
  title        = {{Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides)}},
  journal      = {FASEB Journal},
  year         = {2026},
  doi          = {10.1096/fj.202602519R},
  note         = {PMID: 42606523},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record TAO2026) [Data set]. https://mtor-atlas.org/study/TAO2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_TAO2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record TAO2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/TAO2026/},
  doi          = {10.5281/zenodo.22059963}
}

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