Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides)

Tao J, Chen S, Liu N, Gong Y, Zhang S, He J, Huang X, Chen N, Li S · 2026 · FASEB Journal · Atlas ID TAO2026

What this study shows

mTOR/SREBP1 signaling governs hepatic glucose partitioning; the insulin-responsive mTOR/SREBP1 axis promotes lipogenesis versus glycogen accumulation. In this model -- a carnivorous fish -- an impaired axis causes hepatic glycogen overload mimicking glucose intolerance.

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Carnivorous fish (hepatic glycogen accumulation model)); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Carnivorous fish (hepatic glycogen accumulation model)
Journal	FASEB Journal
Year	2026
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1096/fj.202602519R · PMID 42606523

Cite this paper

ShowHide

Tao, J., Chen, S., Liu, N., Gong, Y., Zhang, S., He, J., Huang, X., Chen, N., & Li, S. (2026). Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides). FASEB Journal. https://doi.org/10.1096/fj.202602519R

@article{TAO2026,
  author       = {Tao, J. and Chen, S. and Liu, N. and Gong, Y. and Zhang, S. and He, J. and Huang, X. and Chen, N. and Li, S.},
  title        = {{Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides)}},
  journal      = {FASEB Journal},
  year         = {2026},
  doi          = {10.1096/fj.202602519R},
  note         = {PMID: 42606523},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record TAO2026) [Data set]. https://mtor-atlas.org/study/TAO2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_TAO2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record TAO2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/TAO2026/},
  doi          = {10.5281/zenodo.22059963}
}