S6K1

Gene/Protein · 8 studies in the Atlas · also known as p70 S6K, p70 S6 kinase, S6 kinase 1, RPS6KB1, p70S6K

Direct downstream effector of mTORC1 controlling protein synthesis; its deletion extends mouse lifespan similarly to caloric restriction.

Evidence at a glance

Study	Year	Tier	Finding
SCH2025	2025	B	First-in-human trial of a bi-steric mTORC1-selective inhibitor. Treatment-related hyperglycemia was low (4%) and not dose-limiting -- direct clinical confirmation that sparing mTORC2 avoids the metabo
SEL2009	2009	C	Deleting S6K1 (a direct mTORC1 effector) extended lifespan and protected against age-related bone, immune, and motor decline in mice.
UMX2004	2004	C	S6K1 deletion protects mice from age- and diet-induced obesity and enhances insulin sensitivity.
DOR2006	2006	D	S6K1 triggers betaTRCP-mediated degradation of the tumour suppressor PDCD4 to promote translation.
HARA2002	2002	D	Independent co-discovery of Raptor (same issue of Cell as Kim 2002). Showed Raptor is essential for mTOR to phosphorylate 4E-BP1 and S6K1, and that knocking it down in worms mimics loss of TOR - confi
KIM2002	2002	D	Discovery of Raptor as the defining partner of mTOR in mTORC1. This is the paper that gives mTORC1 its identity: Raptor is the scaffold that lets mTOR find and phosphorylate its targets (S6K1), and th
KUO1992	1992	D	Rapamycin selectively inhibits IL-2-driven activation of p70 S6 kinase during T-cell proliferation.
PRI1992	1992	D	Rapamycin induces dephosphorylation/inactivation of the 70 kDa S6 kinase, defining an early readout of TOR signalling.