Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G · 2004 · Nature · Atlas ID UMX2004

What this study shows

S6K1 deletion protects mice from age- and diet-induced obesity and enhances insulin sensitivity.

Abstract

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Elucidating the signalling mechanisms by which obesity leads to impaired insulin action is critical in the development of therapeutic strategies for the treatment of diabetes. Recently, mice deficient for S6 Kinase 1 (S6K1), an effector of the mammalian target of rapamycin (mTOR) that acts to integrate nutrient and insulin signals, were shown to be hypoinsulinaemic, glucose intolerant and have reduced beta-cell mass.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse (S6K1 KO)); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse (S6K1 KO)
Journal	Nature
Year	2004
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/nature02866 · PMID 15306821

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic – S6K1 knockout
Target	S6K1 (downstream of mTORC1)
Model	Mouse (S6K1 KO)
Effect	S6K1 loss protects against age- and diet-induced obesity and enhances insulin sensitivity

In the Atlas

Links in the pathway map

Supports S6K1 inhibits IRS-1 / IRS-2

Cite this paper

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Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., & Thomas, G. (2004). Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. https://doi.org/10.1038/nature02866

@article{UMX2004,
  author       = {Um, S. H. and Frigerio, F. and Watanabe, M. and Picard, F. and Joaquin, M. and Sticker, M. and Fumagalli, S. and Allegrini, P. R. and Kozma, S. C. and Auwerx, J. and Thomas, G.},
  title        = {{Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity}},
  journal      = {Nature},
  year         = {2004},
  doi          = {10.1038/nature02866},
  note         = {PMID: 15306821},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record UMX2004) [Data set]. https://mtor-atlas.org/study/UMX2004/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_UMX2004,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record UMX2004},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/UMX2004/},
  doi          = {10.5281/zenodo.22059963}
}

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