Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Elucidating the signalling mechanisms by which obesity leads to impaired insulin action is critical in the development of therapeutic strategies for the treatment of diabetes. Recently, mice deficient for S6 Kinase 1 (S6K1), an effector of the mammalian target of rapamycin (mTOR) that acts to integrate nutrient and insulin signals, were shown to be hypoinsulinaemic, glucose intolerant and have reduced beta-cell mass.

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Um, S. H., et al. (2004). Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. https://doi.org/10.1038/nature02866

@article{UMX2004,
  author       = {Um, S. H. and Thomas, G. and others},
  title        = {{Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity}},
  journal      = {Nature},
  year         = {2004},
  doi          = {10.1038/nature02866},
  note         = {PMID: 15306821},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record UMX2004) [Data set]. https://mtor-atlas.org/study/UMX2004/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_UMX2004,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record UMX2004},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/UMX2004/},
  doi          = {10.5281/zenodo.22059963}
}