S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M · 2006 · Science · Atlas ID DOR2006

What this study shows

S6K1 triggers betaTRCP-mediated degradation of the tumour suppressor PDCD4 to promote translation.

Abstract

ShowHide

The tumor suppressor programmed cell death protein 4 (PDCD4) inhibits the translation initiation factor eIF4A, an RNA helicase that catalyzes the unwinding of secondary structure at the 5' untranslated region (5'UTR) of messenger RNAs (mRNAs). In response to mitogens, PDCD4 was rapidly phosphorylated on Ser67 by the protein kinase S6K1 and subsequently degraded via the ubiquitin ligase SCF(betaTRCP).

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Science
Year	2006
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1126/science.1130276 · PMID 17053147

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical/genetic (S6K1, βTRCP, PDCD4)
Target	S6K1 / PDCD4 / eIF4A
Model	Mammalian cells
Effect	S6K1 phosphorylates PDCD4 (Ser67) triggering βTRCP-mediated degradation → promotes translation and cell growth

In the Atlas

Links in the pathway map

Supports S6K1 inhibits PDCD4

Cite this paper

ShowHide

Dorrello, N. V., Peschiaroli, A., Guardavaccaro, D., Colburn, N. H., Sherman, N. E., & Pagano, M. (2006). S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science. https://doi.org/10.1126/science.1130276

@article{DOR2006,
  author       = {Dorrello, N. V. and Peschiaroli, A. and Guardavaccaro, D. and Colburn, N. H. and Sherman, N. E. and Pagano, M.},
  title        = {{S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth}},
  journal      = {Science},
  year         = {2006},
  doi          = {10.1126/science.1130276},
  note         = {PMID: 17053147},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DOR2006) [Data set]. https://mtor-atlas.org/study/DOR2006/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DOR2006,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DOR2006},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DOR2006/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?