Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling pathways implicated in muscle hypertrophy on the basis of findings in vitro, Akt/mTOR (mammalian target of rapamycin) and calcineurin/NFAT (nuclear factor of activated T cells), were investigated in several models of skeletal muscle hypertrophy and atrophy in vivo. The Akt/mTOR pathway was upregulated during hypertrophy and downregulated during muscle atrophy.

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Bodine, S. C., et al. (2001). Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nature cell biology. https://doi.org/10.1038/ncb1101-1014

@article{BOD2001,
  author       = {Bodine, S. C. and Yancopoulos, G. D. and others},
  title        = {{Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo}},
  journal      = {Nature cell biology},
  year         = {2001},
  doi          = {10.1038/ncb1101-1014},
  note         = {PMID: 11715023},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BOD2001) [Data set]. https://mtor-atlas.org/study/BOD2001/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BOD2001,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BOD2001},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BOD2001/},
  doi          = {10.5281/zenodo.22059963}
}