Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR · 1992 · Nature · Atlas ID KUO1992

What this study shows

Rapamycin selectively inhibits IL-2-driven activation of p70 S6 kinase during T-cell proliferation.

Abstract

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The macrolide rapamycin induces cell cycle G1 arrest in yeast and in mammalian cells, which suggests that an evolutionarily conserved, rapamycin-sensitive pathway may regulate entry into S phase. In mammals, rapamycin inhibits interleukin-2 receptor-induced S phase entry and subsequent T-cell proliferation, resulting in immunosuppression. Here we show that interleukin-2 selectively stimulates the phosphorylation and activation of p70 S6 kinase but not the erk-encoded MAP kinases and rsk-encoded S6 kinases.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: T cells; in vitro) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	T cells; in vitro
Journal	Nature
Year	1992
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/358070a0 · PMID 1614535

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Rapamycin
Target	p70 S6 kinase (IL-2 signaling)
Model	T cells; in vitro
Effect	Rapamycin selectively inhibits IL-2-induced activation of p70 S6 kinase (basis of immunosuppression)

In the Atlas

Cite this paper

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Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J., & Crabtree, G. R. (1992). Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature. https://doi.org/10.1038/358070a0

@article{KUO1992,
  author       = {Kuo, C. J. and Chung, J. and Fiorentino, D. F. and Flanagan, W. M. and Blenis, J. and Crabtree, G. R.},
  title        = {{Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase}},
  journal      = {Nature},
  year         = {1992},
  doi          = {10.1038/358070a0},
  note         = {PMID: 1614535},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KUO1992) [Data set]. https://mtor-atlas.org/study/KUO1992/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KUO1992,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KUO1992},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KUO1992/},
  doi          = {10.5281/zenodo.22059963}
}

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