Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

The macrolide rapamycin induces cell cycle G1 arrest in yeast and in mammalian cells, which suggests that an evolutionarily conserved, rapamycin-sensitive pathway may regulate entry into S phase. In mammals, rapamycin inhibits interleukin-2 receptor-induced S phase entry and subsequent T-cell proliferation, resulting in immunosuppression. Here we show that interleukin-2 selectively stimulates the phosphorylation and activation of p70 S6 kinase but not the erk-encoded MAP kinases and rsk-encoded S6 kinases.

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Kuo, C. J., et al. (1992). Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature. https://doi.org/10.1038/358070a0

@article{KUO1992,
  author       = {Kuo, C. J. and Crabtree, G. R. and others},
  title        = {{Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase}},
  journal      = {Nature},
  year         = {1992},
  doi          = {10.1038/358070a0},
  note         = {PMID: 1614535},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KUO1992) [Data set]. https://mtor-atlas.org/study/KUO1992/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KUO1992,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KUO1992},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KUO1992/},
  doi          = {10.5281/zenodo.22059963}
}