SREBP1 / SREBP2
Sterol regulatory element-binding proteins 1 and 2; master transcription factors for de novo lipid and cholesterol biosynthesis. mTORC1 promotes SREBP nuclear entry (via Lipin-1 and S6K1), linking nutrient sensing to the lipogenic program. SREBP1/2 are thus a major downstream metabolic output of mTORC1 alongside protein synthesis and autophagy suppression.
The switch for making fat. Master genetic switches for building new fats and cholesterol from scratch. mTORC1 helps move them into the nucleus to switch these genes on, linking nutrient signals to fat-making, alongside its roles in protein building and blocking cleanup.
Regulated via S6K1 and Lipin-1 nuclear exclusion; the link is indirect and partly cell-type specific.
TL;DR. SREBP1 / SREBP2 appears in 4 curated studies in Oliver's mTOR Atlas: 1 in animal models; 2 at the molecular level (cells, biochemistry, structure); 1 review. No study in people is recorded for it in the Atlas yet. It has 2 interactions in the curated pathway model.
In the pathway model
| Interaction | Mechanism | Evidence | Studies |
|---|---|---|---|
| SREBP1 / SREBP2 activates Lipid synthesis mechanism: transcriptional · this link in full · on the map table | SREBP is the master switch for making new fat from scratch. SREBP1 is the main transcriptional switch for de novo lipogenesis, and SREBP2 for cholesterol synthesis. SREBP1 is the main transcriptional switch for de novo lipogenesis, and SREBP2 for cholesterol synthesis. Holds under: Mammalian cell studies and a review (POR2008, PET2011, SHI2014). SREBP's role in lipid synthesis rests on cell-based work and does not measure it in people. plausible in people, not shown directly · settled in the literature | M | POR2008, PET2011, SHI2014 |
| mTORC1 activates SREBP1 / SREBP2 mechanism: signal-relay · this link in full · on the map table | mTORC1 switches on SREBP, the genes that build fat and cholesterol – a growing cell needs membrane material, not just protein. mTORC1 drives the SREBP transcription factors, which turn on the genes for making fat and cholesterol - growth needs membrane, not just protein. mTORC1 drives the SREBP transcription factors, which turn on the genes for making fat and cholesterol - growth needs membrane, not just protein. Holds under: Mammalian cell studies (POR2008, PET2011) and an emerging rather than settled consensus. Cultured cells; the size of the effect in whole animals and in people is not measured by these studies. plausible in people, not shown directly · emerging, few independent studies | M | POR2008, PET2011 |
Evidence at a glance
| Evidence | What it means | Studies |
|---|---|---|
| A | Animal model | 1 |
| M | Molecular — cells, biochemistry, structure | 2 |
| R | Review — secondary literature, not a new result | 1 |
No direct human evidence in the Atlas for this entity yet — everything below rests on animal or molecular work.
Studies
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides) TAO2026 mTOR/SREBP1 signaling governs hepatic glucose partitioning; the insulin-responsive mTOR/SREBP1 axis promotes lipogenesis versus glycogen accumulation. In this model -- a carnivorous fish -- impairment of the axis is associated with hepatic glycogen overload mimicking glucose intolerance. |
| 2014 | R | Making new contacts: the mTOR network in metabolism and signalling crosstalk SHI2014 Review of the mTOR network in metabolism and signalling crosstalk. |
| 2011 | M | mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway PET2011 mTORC1 controls lipin-1 nuclear localization to regulate SREBP and lipid synthesis. |
| 2008 | M | SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth POR2008 mTORC1 activates SREBP to drive lipogenesis supporting Akt-dependent cell growth. |
Related entities
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