Defining subunit of mTORC2 (Rapamycin-Insensitive Companion of mTOR); routes mTOR toward Akt and the cytoskeleton rather than S6K1/4E-BP1.
| Tier | What it means | Studies |
|---|---|---|
| D | Mechanistic / in vitro / review | 3 |
No direct human evidence in the Atlas for this entity yet — everything below rests on animal or mechanistic work.
| Study | Year | Tier | Finding |
|---|---|---|---|
| GUE2006 | 2006 | D | The definitive genetic 'dissection' of the two complexes in living mice. Deleting Raptor was lethal early (mTORC1 essential); deleting Rictor or mLST8 selectively knocked out mTORC2 signaling to Akt a |
| SAR2006 | 2006 | D | The molecular explanation for rapamycin's dark side. Short-term rapamycin only hits mTORC1, but LONG-term treatment also strips down mTORC2 in many cells, cutting Akt signaling. This is the mechanisti |
| SAR2004 | 2004 | D | Discovery of Rictor and the SECOND mTOR complex, mTORC2. Crucially showed this complex is NOT blocked by rapamycin and does not use Raptor - it controls the cytoskeleton via PKC. This is the paper tha |