Cell shape and motility machinery. The first function ever attributed to mTORC2 - and noticed precisely because rapamycin failed to block it.
The cell's internal scaffolding.
The original TORC2 phenotype in yeast; in mammals mediated through PKCα and Rho GTPases and largely rapamycin-insensitive acutely.
| Tier | What it means | Studies |
|---|---|---|
| D | Mechanistic / in vitro / review | 3 |
No direct human evidence in the Atlas for this entity yet — everything below rests on animal or mechanistic work.
| Study | Year | Tier | Finding |
|---|---|---|---|
| JAC2004 | 2004 | D | mTORC2 (rictor) controls the actin cytoskeleton and is rapamycin-insensitive, defining a second mTOR complex in mammals. |
| SAR2004 | 2004 | D | Discovery of Rictor and the SECOND mTOR complex, mTORC2. Crucially showed this complex is NOT blocked by rapamycin and does not use Raptor - it controls the cytoskeleton via PKC. This is the paper tha |
| LOE2002 | 2002 | D | Defined two distinct TOR complexes, only one rapamycin-sensitive, founding the TORC1/TORC2 paradigm. |