Oliver's mTOR Atlas Evidence Platform
Reading level
Mode

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Loewith R, Hall MN et al. · 2002 · Molecular cell · Atlas ID LOE2002

What this study shows

Defined two distinct TOR complexes, only one rapamycin-sensitive, founding the TORC1/TORC2 paradigm.

Abstract

ShowHide

The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin-sensitive manner. TOR2 additionally regulates polarization of the actin cytoskeleton in a rapamycin-insensitive manner. We describe two functionally distinct TOR complexes. TOR Complex 1 (TORC1) contains TOR1 or TOR2, KOG1 (YHR186c), and LST8. TORC2 contains TOR2, AVO1 (YOL078w), AVO2 (YMR068w), AVO3 (YER093c), and LST8.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Yeast S. cerevisiae) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemYeast S. cerevisiae
JournalMolecular cell
Year2002
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1016/s1097-2765(02)00636-6 · PMID 12408816

Extracted findings

InterventionGenetic/biochemical (TOR1/TOR2 complexes)
TargetTORC1 / TORC2
ModelYeast (S. cerevisiae)
EffectDefines two TOR complexes: TORC1 (rapamycin-sensitive, growth) and TORC2 (rapamycin-insensitive, actin)

In the Atlas

Related topics

Actin cytoskeleton

More studies on this topic

Learn the biology

Want to understand the biology behind this study? → mTORC1 vs mTORC2

Cite this paper

ShowHide 
Loewith, R., et al. (2002). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Molecular cell. https://doi.org/10.1016/s1097-2765(02)00636-6

@article{LOE2002,
  author       = {Loewith, R. and Hall, M. N. and others},
  title        = {{Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control}},
  journal      = {Molecular cell},
  year         = {2002},
  doi          = {10.1016/s1097-2765(02)00636-6},
  note         = {PMID: 12408816},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record LOE2002) [Data set]. https://mtor-atlas.org/study/LOE2002/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LOE2002,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LOE2002},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LOE2002/},
  doi          = {10.5281/zenodo.22059963}
}