Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of cell growth. In budding yeast, TOR is found in structurally and functionally distinct protein complexes: TORC1 and TORC2. A mammalian counterpart of TORC1 (mTORC1) has been described, but it is not known whether TORC2 is conserved in mammals. Here, we report that a mammalian counterpart of TORC2 (mTORC2) also exists. mTORC2 contains mTOR, mLST8 and mAVO3, but not raptor. Like yeast TORC2, mTORC2 is rapamycin insensitive and seems to function upstream of Rho GTPases to regulate the actin cytoskeleton.

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Jacinto, E., et al. (2004). Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nature cell biology. https://doi.org/10.1038/ncb1183

@article{JAC2004,
  author       = {Jacinto, E. and Hall, M. N. and others},
  title        = {{Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive}},
  journal      = {Nature cell biology},
  year         = {2004},
  doi          = {10.1038/ncb1183},
  note         = {PMID: 15467718},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record JAC2004) [Data set]. https://mtor-atlas.org/study/JAC2004/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_JAC2004,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record JAC2004},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/JAC2004/},
  doi          = {10.5281/zenodo.22059963}
}