mTORC2 controls actin polymerization required for consolidation of long-term memory

Huang W, Zhu PJ, Zhang S, Zhou H, Stoica L, Galiano M, Krnjevic K, Roman G, Costa-Mattioli M · 2013 · Nature Neuroscience · Atlas ID HUA2013

What this study shows

Conditional deletion of Rictor in the postnatal mouse forebrain reduced mTORC2 activity and selectively impaired long-term memory and the late phase of hippocampal LTP, with a comparable long-term-memory deficit in dTORC2-deficient flies. Hippocampal actin polymerisation was reduced, and restoring it rescued both L-LTP and long-term memory; a compound that raised mTORC2 activity converted early LTP into late LTP and enhanced memory. This is the loss-of-function AND rescue evidence that mTORC2 is required for memory consolidation - the arm chronic rapamycin also disrupts, and the study Open Question H8 needs for its mTORC2 liability leg, which until 2026-09-05 rested on no supporting study at all.

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Conditional Rictor-knockout mice (postnatal forebrain) and Drosophila); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Conditional Rictor-knockout mice (postnatal forebrain) and Drosophila
Journal	Nature Neuroscience
Year	2013
Peer reviewed	—
Record last updated	2026-08-22
Source	DOI 10.1038/nn.3351 · PMID 23455608 · Free full text (PMC3615448)

Extracted findings

Intervention	Conditional postnatal forebrain Rictor deletion; dTORC2-deficient flies; actin-polymerisation rescue; mTORC2-activating compound
Target	mTORC2 / Rictor; actin polymerisation
Model	Mouse; Drosophila
Effect	Rictor deletion impairs long-term memory and late-phase LTP; restoring actin polymerisation rescues both

Cite this paper

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Huang, W., Zhu, P. J., Zhang, S., Zhou, H., Stoica, L., Galiano, M., Krnjevic, K., Roman, G., & Costa-Mattioli, M. (2013). mTORC2 controls actin polymerization required for consolidation of long-term memory. Nature Neuroscience. https://doi.org/10.1038/nn.3351

@article{HUA2013,
  author       = {Huang, W. and Zhu, P. J. and Zhang, S. and Zhou, H. and Stoica, L. and Galiano, M. and Krnjevic, K. and Roman, G. and Costa-Mattioli, M.},
  title        = {{mTORC2 controls actin polymerization required for consolidation of long-term memory}},
  journal      = {Nature Neuroscience},
  year         = {2013},
  doi          = {10.1038/nn.3351},
  note         = {PMID: 23455608},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record HUA2013) [Data set]. https://mtor-atlas.org/study/HUA2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HUA2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HUA2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HUA2013/},
  doi          = {10.5281/zenodo.22059963}
}