Wolfgang Oppliger
Long-serving Biozentrum researcher who worked for more than two decades in Basel labs, first on how proteins enter mitochondria and then on TOR signalling with Michael Hall
Biozentrum, University of Basel, Michael N. Hall lab (about 2002–2014) · Biozentrum, University of Basel, Gottfried Schatz lab (1991–1997, mitochondrial protein import) · current position not confirmed
In 2012 Raul Duran and colleagues in Michael Hall's lab showed that glutaminolysis, the breakdown of the amino acid glutamine, switches on mTORC1, the growth-control complex. Glutamine is turned into alpha-ketoglutarate, and this metabolite activates the Rag proteins that bring mTORC1 to the lysosome, where it is switched on. The result linked a common nutrient to mTORC1 through a specific chemical step. It was shown in cultured cells. Wolfgang Oppliger is one of the co-authors.
Oppliger's name runs through Biozentrum papers for more than twenty years. In the 1990s, Oppliger co-authored studies from Gottfried Schatz's lab on how proteins made in the cytoplasm are imported into yeast mitochondria, including work on the mitochondrial processing protease (1991) and on how the import machines of the outer and inner mitochondrial membranes work together (1995).
From the early 2000s, Oppliger appears on TOR papers from Michael Hall's group: the 2002 Molecular Cell paper that described the two yeast TOR complexes, a 2005 study of how TOR complex 2 is organised, the 2011 Cell paper showing that mTORC2 is activated by ribosomes, and a 2014 mouse study showing that mTORC1 in the liver controls body temperature, movement and fat metabolism through the hormone FGF21. Oppliger's exact role and current position could not be confirmed.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2012 | M | Glutaminolysis activates Rag-mTORC1 signaling DUR2012 Co-author: glutaminolysis activates Rag-mTORC1 signalling through alpha-ketoglutarate. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Wolfgang Oppliger.
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- Michael N. Hall Discovered TOR in yeast in 1991 and established it as a central controller of cell growth that responds to nutrients. His lab later showed that TOR works in two distinct complexes, TORC1 and TORC2, only one of which is blocked by rapamycin
- Raúl V. Durán Cell biologist who showed that glutamine breakdown feeds amino acid signalling to mTORC1, and who now leads research on mTOR, glutamine metabolism and cancer at CABIMER in Seville
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