Pathway link MTORC1-SREBP

mTORC1 → SREBP1 / SREBP2

mTORC1 activates SREBP1 / SREBP2.

mTORC1 switches on SREBP, the genes that build fat and cholesterol – a growing cell needs membrane material, not just protein.

mTORC1 drives the SREBP transcription factors, which turn on the genes for making fat and cholesterol - growth needs membrane, not just protein.

The conditions it holds under

Mammalian cell studies (POR2008, PET2011) and an emerging rather than settled consensus. Cultured cells; the size of the effect in whole animals and in people is not measured by these studies.

Time it takes

hours

Step

indirect (through steps not drawn here)

Measured in

mammalian cells

Where in the cell

cytosol

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

← The whole pathway · This link as JSON