SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Cell growth (accumulation of mass) needs to be coordinated with metabolic processes that are required for the synthesis of macromolecules. The PI3-kinase/Akt signaling pathway induces cell growth via activation of complex 1 of the target of rapamycin (TORC1). Here we show that Akt-dependent lipogenesis requires mTORC1 activity. Furthermore, nuclear accumulation of the mature form of the sterol responsive element binding protein (SREBP1) and expression of SREBP target genes was blocked by the mTORC1 inhibitor rapamycin.

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Porstmann, T., et al. (2008). SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell metabolism. https://doi.org/10.1016/j.cmet.2008.07.007

@article{POR2008,
  author       = {Porstmann, T. and Schulze, A. and others},
  title        = {{SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth}},
  journal      = {Cell metabolism},
  year         = {2008},
  doi          = {10.1016/j.cmet.2008.07.007},
  note         = {PMID: 18762023},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record POR2008) [Data set]. https://mtor-atlas.org/study/POR2008/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_POR2008,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record POR2008},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/POR2008/},
  doi          = {10.5281/zenodo.22059963}
}