SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A · 2008 · Cell metabolism · Atlas ID POR2008

What this study shows

mTORC1 activates SREBP to drive lipogenesis supporting Akt-dependent cell growth.

Abstract

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Cell growth (accumulation of mass) needs to be coordinated with metabolic processes that are required for the synthesis of macromolecules. The PI3-kinase/Akt signaling pathway induces cell growth via activation of complex 1 of the target of rapamycin (TORC1). Here we show that Akt-dependent lipogenesis requires mTORC1 activity. Furthermore, nuclear accumulation of the mature form of the sterol responsive element binding protein (SREBP1) and expression of SREBP target genes was blocked by the mTORC1 inhibitor rapamycin.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Cell metabolism
Year	2008
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cmet.2008.07.007 · PMID 18762023 · Free full text (PMC2593919)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/pharmacologic (mTORC1/SREBP)
Target	mTORC1 / SREBP / Akt
Model	Mammalian cells
Effect	SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth (lipogenesis)

In the Atlas

Links in the pathway map

Supports mTORC1 activates SREBP1 / SREBP2
Supports SREBP1 / SREBP2 activates Lipid synthesis

Cite this paper

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Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y. L., & Schulze, A. (2008). SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell metabolism. https://doi.org/10.1016/j.cmet.2008.07.007

@article{POR2008,
  author       = {Porstmann, T. and Santos, C. R. and Griffiths, B. and Cully, M. and Wu, M. and Leevers, S. and Griffiths, J. R. and Chung, Y. L. and Schulze, A.},
  title        = {{SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth}},
  journal      = {Cell metabolism},
  year         = {2008},
  doi          = {10.1016/j.cmet.2008.07.007},
  note         = {PMID: 18762023},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record POR2008) [Data set]. https://mtor-atlas.org/study/POR2008/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_POR2008,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record POR2008},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/POR2008/},
  doi          = {10.5281/zenodo.22059963}
}

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