Pathway link SREBP-LIPID
SREBP1 / SREBP2 Lipid synthesis
SREBP1 / SREBP2 activates Lipid synthesis.
SREBP is the master switch for making new fat from scratch.
The conditions it holds under
Mammalian cell studies and a review (POR2008, PET2011, SHI2014). SREBP's role in lipid synthesis rests on cell-based work and does not measure it in people.
- Time it takes
- hours
- Step
- direct (one molecule acts on the other)
- Measured in
- mammalian cells
- Where in the cell
- nucleus
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2008 | M | SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growthPOR2008 mTORC1 activates SREBP to drive lipogenesis supporting Akt-dependent cell growth. |
| 2011 | M | mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayPET2011 mTORC1 controls lipin-1 nuclear localization to regulate SREBP and lipid synthesis. |
| 2014 | R | Making new contacts: the mTOR network in metabolism and signalling crosstalkSHI2014 Review of the mTOR network in metabolism and signalling crosstalk. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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