{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "SREBP-LIPID",
  "claim": "SREBP1 / SREBP2 activates Lipid synthesis",
  "source": {
   "name": "SREBP1 / SREBP2",
   "entity": "srebp1-srebp2"
  },
  "target": {
   "name": "Lipid synthesis",
   "entity": "lipid-synthesis"
  },
  "effect": "activates",
  "type": "transcriptional",
  "directness": "direct",
  "timescale": "hours",
  "compartment": "nucleus",
  "map_band": "nucleus",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "SREBP1 is the main transcriptional switch for de novo lipogenesis, and SREBP2 for cholesterol synthesis.",
  "mechanism_beginner": "SREBP is the master switch for making new fat from scratch.",
  "context": null,
  "boundary": "Mammalian cell studies and a review (POR2008, PET2011, SHI2014). SREBP's role in lipid synthesis rests on cell-based work and does not measure it in people.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "POR2008",
    "PET2011",
    "SHI2014"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/SREBP-LIPID/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/SREBP-LIPID.json"
 }
}