Shiwen Chen
Aquaculture physiologist studying why the largemouth bass, a carnivorous fish, tolerates dietary carbohydrate so poorly
Aquaculture nutrition researcher · Shanghai Ocean University
Chen and colleagues compared largemouth bass with tilapia on graded-carbohydrate diets and traced bass's poor carbohydrate tolerance to a blunted insulin → AKT1 → mTOR → SREBP1 signaling axis. Using gene knockdown in bass liver cells, the team showed the chain of command directly: silencing akt1 or s6k1 blocked SREBP1 activation, silencing tsc2 restored mTOR signaling, and blocking mTOR with rapamycin reproduced the glycogen-overload phenotype.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides) TAO2026 Second author on a comparative fish physiology study showing largemouth bass have a blunted insulin/AKT1/mTOR/SREBP1 axis that diverts excess dietary carbohydrate into liver glycogen rather than fat. |
Co-authors in the Atlas 4
People with a profile here who share at least one study with Shiwen Chen.
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- Jiajie Tao Fish nutrition researcher at Shanghai Ocean University who studies why carnivorous farmed fish such as largemouth bass handle dietary carbohydrate poorly and how this links to mTOR signalling in the liver
- Jiaxiong He Contributing co-author in Songlin Li's aquaculture-nutrition team studying mTOR/SREBP1-driven lipogenesis in fish.
- Sen Zhang Contributed to a study showing that largemouth bass have a weak insulin/mTOR/SREBP1 fat-making pathway, so excess dietary carbohydrate is stored as liver glycogen rather than fat
- Songlin Li Fish nutrition scientist at Shanghai Ocean University who leads research on how largemouth bass and other farmed fish use carbohydrate and other nutrients in their feed
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