Shiwen Chen
Aquaculture physiologist studying why the largemouth bass, a carnivorous fish, tolerates dietary carbohydrate so poorly
Aquaculture nutrition researcher · Shanghai Ocean University
Chen and colleagues compared largemouth bass with tilapia on graded-carbohydrate diets and traced bass's poor carbohydrate tolerance to a blunted insulin → AKT1 → mTOR → SREBP1 signaling axis. Using gene knockdown in bass liver cells, the team showed the chain of command directly: silencing akt1 or s6k1 blocked SREBP1 activation, silencing tsc2 restored mTOR signaling, and blocking mTOR with rapamycin reproduced the glycogen-overload phenotype.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides) TAO2026 Second author on a comparative fish physiology study showing largemouth bass have a blunted insulin/AKT1/mTOR/SREBP1 axis that diverts excess dietary carbohydrate into liver glycogen rather than fat. |
Co-authors in the Atlas
People with a profile here who share at least one study with Shiwen Chen.
- Jiaxiong He Contributing co-author in Songlin Li's aquaculture-nutrition team studying mTOR/SREBP1-driven lipogenesis in fish.
- Sen Zhang Contributed to a study showing that largemouth bass have a weak insulin/mTOR/SREBP1 fat-making pathway, so excess dietary carbohydrate is stored as liver glycogen rather than fat