The role of mTORC2/RICTOR in immune cells and inflammatory diseases.

Xu J, Zhong W, Xin F, Xu F, Zheng Z, Guo F · 2026 · Inflammation Research · Atlas ID XU2026B

What this study shows

mTORC2/RICTOR signaling (via AKT, SGK1, PKC) shapes Th1/Th2 differentiation, Treg stability, memory T cell formation, BCR signaling and plasma cell survival, and macrophage/DC/NK function; its role in tissue inflammation is context-dependent (exacerbating osteoarthritis and pancreatitis but restraining pro-inflammatory polarization in colorectal cancer), and dual mTORC1/2 inhibitors (e.g. AZD2014) show early but complicated promise.

Abstract

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mTORC2, defined by its core component RICTOR, is a key regulator of immune cell function and inflammation, yet its roles have long been underappreciated due to lack of specific inhibitors and in vivo tools. This review summarizes the current understanding of mTORC2-specific signaling (via AKT, SGK1, and PKC) in regulating the development, differentiation, and effector functions of diverse immune cells, and discusses its emerging roles in immune cell inflammation and tissue-specific inflammation.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review of immune cell subsets (T cells, B cells, macrophages, dendritic cells, NK cells) and mouse conditional-knockout models
Journal	Inflammation Research
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1007/s00011-026-02365-9 · PMID 42752901 · Free full text (PMC13586041)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	none (review)
Target	mTORC2/RICTOR in immune cells
Model	Review (mouse conditional knockouts, immune cells, clinical samples)
Effect	Summarises context-dependent roles of mTORC2 in immune cell differentiation and tissue inflammation.

In the Atlas

Cite this paper

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Xu, J., Zhong, W., Xin, F., Xu, F., Zheng, Z., & Guo, F. (2026). The role of mTORC2/RICTOR in immune cells and inflammatory diseases. Inflammation Research. https://doi.org/10.1007/s00011-026-02365-9

@article{XU2026B,
  author       = {Xu, J. and Zhong, W. and Xin, F. and Xu, F. and Zheng, Z. and Guo, F.},
  title        = {{The role of mTORC2/RICTOR in immune cells and inflammatory diseases}},
  journal      = {Inflammation Research},
  year         = {2026},
  doi          = {10.1007/s00011-026-02365-9},
  note         = {PMID: 42752901},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record XU2026B) [Data set]. https://mtor-atlas.org/study/XU2026B/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_XU2026B,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record XU2026B},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/XU2026B/},
  doi          = {10.5281/zenodo.22059963}
}

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