Jingting Xu
Researcher in the orthopedics department of Tongji Hospital, Wuhan, and first author of a 2026 review on mTORC2 and its partner RICTOR in immune cells and inflammatory disease
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (at the time of the study, 2026)
Most writing on mTOR is about mTORC1, the complex that drives growth. Jingting Xu's 2026 review in Inflammation Research, with Fengjing Guo as senior author, collects what is known about the second complex, mTORC2, and its defining partner RICTOR in the immune system. mTORC2 acts through the kinases AKT, SGK1 and PKC.
The review describes how mTORC2 shapes the choice between Th1 and Th2 helper T cells, keeps regulatory T cells stable, helps memory T cells form, and affects B-cell receptor signalling, plasma cell survival, and the behaviour of macrophages, dendritic cells and natural killer cells. In tissues its effect depends on context: it worsens inflammation in osteoarthritis and pancreatitis but restrains pro-inflammatory macrophages in colorectal cancer. Drugs that block both mTOR complexes, such as AZD2014, show early but complicated promise. The paper is a review of published work, not new data.
PubMed lists Jingting Xu at the Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Because the name is common, no wider publication record is attributed here.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | R | The role of mTORC2/RICTOR in immune cells and inflammatory diseases. XU2026B First author: wrote the review of mTORC2/RICTOR signalling across T cells, B cells and innate immune cells and its context-dependent role in inflammatory disease. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Jingting Xu.
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- Fengjing Guo Orthopedic researcher at Tongji Hospital, Wuhan, and senior author of a 2026 review on how mTORC2 and RICTOR shape immune cells and inflammation
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