Fengjing Guo

Orthopedic researcher at Tongji Hospital, Wuhan, and senior author of a 2026 review on how mTORC2 and RICTOR shape immune cells and inflammation

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (at the time of the study, 2026)

Fengjing Guo is the senior author of a 2026 review, led by Jingting Xu, on mTORC2, the less studied of the two mTOR complexes, and its essential partner RICTOR. mTORC2 passes its signals through the kinases AKT, SGK1 and PKC, and the review follows these signals through T cells, B cells, macrophages, dendritic cells and natural killer cells.

One theme of the review is relevant to an orthopedics department: mTORC2 signalling makes inflammation worse in osteoarthritis, the joint disease in which cartilage wears away, and in pancreatitis, yet it restrains pro-inflammatory macrophages in colorectal cancer. The authors conclude that dual mTORC1/2 inhibitors such as AZD2014 show early but complicated promise. The paper summarises published studies and adds no new experiments.

PubMed lists Guo at the Department of Orthopedics of Tongji Hospital, part of Tongji Medical College of Huazhong University of Science and Technology in Wuhan, where Guo has co-authored papers with Hongbo You, senior author of another osteoarthritis study in this Atlas. Career details could not be confirmed from an official page.

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Co-authors in the Atlas 1

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