The TSC-mTOR signaling pathway regulates the innate inflammatory response

Weichhart T, Saemann MD et al. · 2008 · Immunity · Atlas ID WEI2008

What this study shows

The TSC-mTOR pathway controls the innate inflammatory response of monocytes/macrophages.

Abstract

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The innate inflammatory immune response must be tightly controlled to avoid damage to the host. Here, we showed that the tuberous sclerosis complex-mammalian target of rapamycin (TSC-mTOR) pathway regulated inflammatory responses after bacterial stimulation in monocytes, macrophages, and primary dendritic cells. Inhibition of mTOR by rapamycin promoted production of proinflammatory cytokines via the transcription factor NF-kappaB but blocked the release of interleukin-10 via the transcription factor STAT3.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mouse/human monocytes) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mouse/human monocytes
Journal	Immunity
Year	2008
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1016/j.immuni.2008.08.012 · PMID 18848473

Extracted findings

Intervention	Rapamycin (mTOR inhibition)
Target	TSC-mTOR / NF-κB
Model	Mouse/human monocytes
Effect	mTOR inhibition promotes pro-inflammatory cytokines via NF-κB – TSC-mTOR regulates the innate inflammatory response

Cite this paper

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Weichhart, T., et al. (2008). The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity. https://doi.org/10.1016/j.immuni.2008.08.012

@article{WEI2008,
  author       = {Weichhart, T. and Saemann, M. D. and others},
  title        = {{The TSC-mTOR signaling pathway regulates the innate inflammatory response}},
  journal      = {Immunity},
  year         = {2008},
  doi          = {10.1016/j.immuni.2008.08.012},
  note         = {PMID: 18848473},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WEI2008) [Data set]. https://mtor-atlas.org/study/WEI2008/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WEI2008,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WEI2008},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WEI2008/},
  doi          = {10.5281/zenodo.22059963}
}