mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

The mechanistic target of rapamycin (mTOR) pathway integrates diverse environmental inputs, including immune signals and metabolic cues, to direct T-cell fate decisions. The activation of mTOR, which is the catalytic subunit of the mTORC1 and mTORC2 complexes, delivers an obligatory signal for the proper activation and differentiation of effector CD4(+) T cells, whereas in the regulatory T-cell (T(reg)) compartment, the Akt-mTOR axis is widely acknowledged as a crucial negative regulator of T(reg)-cell de novo differentiation and population expansion.

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Zeng, H., et al. (2013). mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature. https://doi.org/10.1038/nature12297

@article{ZEN2013,
  author       = {Zeng, H. and Chi, H. and others},
  title        = {{mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function}},
  journal      = {Nature},
  year         = {2013},
  doi          = {10.1038/nature12297},
  note         = {PMID: 23812589},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ZEN2013) [Data set]. https://mtor-atlas.org/study/ZEN2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ZEN2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ZEN2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ZEN2013/},
  doi          = {10.5281/zenodo.22059963}
}