Regulation and function of mTOR signalling in T cell fate decisions

Chi H · 2012 · Nature reviews. Immunology · Atlas ID CHI2012

What this study shows

Review of mTOR signalling in T-cell fate decisions.

Abstract

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The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR signalling to integrate immune signals and metabolic cues for their proper maintenance and activation. Under steady-state conditions, mTOR is actively controlled by multiple inhibitory mechanisms, and this enforces normal T cell homeostasis. Antigen recognition by naive CD4(+) and CD8(+) T cells triggers mTOR activation, which in turn programmes the differentiation of these cells into functionally distinct lineages.

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At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Nature reviews. Immunology
Year	2012
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/nri3198 · PMID 22517423 · Free full text (PMC3417069)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTOR / mTORC1 & mTORC2
Model	Review
Effect	mTOR integrates immune and metabolic cues to program T-cell homeostasis, activation and differentiation

In the Atlas

Cite this paper

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Chi, H. (2012). Regulation and function of mTOR signalling in T cell fate decisions. Nature reviews. Immunology. https://doi.org/10.1038/nri3198

@article{CHI2012,
  author       = {Chi, H.},
  title        = {{Regulation and function of mTOR signalling in T cell fate decisions}},
  journal      = {Nature reviews. Immunology},
  year         = {2012},
  doi          = {10.1038/nri3198},
  note         = {PMID: 22517423},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record CHI2012) [Data set]. https://mtor-atlas.org/study/CHI2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_CHI2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record CHI2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/CHI2012/},
  doi          = {10.5281/zenodo.22059963}
}

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