Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC.

Wang Q, Xin Y, Zokaei E, Zeng L, Piecoro D, Chen M, Zhang Y, Yang KS, Wang C, Liu X, Yang HS · 2026 · Neoplasia · Atlas ID WANG2026B

What this study shows

Pdcd4 binds Rictor via residues R105/K108/R110 to disrupt mTORC2 assembly and kinase activity, lowering PFKFB3 levels and suppressing glycolysis and NSCLC tumour growth.

Abstract

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Programmed cell death 4 (Pdcd4) is a tumour suppressor and inhibitor of protein translation with emerging translation-independent functions. Pdcd4 suppresses tumorigenesis by disrupting mTORC2 complex formation through binding Rictor. Deletion mapping and site-directed mutagenesis defined the Rictor-binding domain of Pdcd4 and identified residues R105, K108 and R110 as critical. Co-immunoprecipitation and in vitro kinase assays showed that Pdcd4 binding to Rictor disrupted mTORC2 assembly and inhibited its kinase activity.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: NSCLC cell lines; mouse xenograft; human tumour tissue) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	NSCLC cell lines; mouse xenograft; human tumour tissue
Journal	Neoplasia
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.neo.2026.101354 · PMID 42648032 · Free full text (PMC13544097)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Pdcd4 overexpression / knockdown; Rictor-binding-deficient mutants
Target	Rictor; mTORC2; PFKFB3
Model	Human cell lines; mouse xenograft
Effect	Disrupted mTORC2 assembly and kinase activity, degraded PFKFB3, suppressed glycolysis and tumour growth

In the Atlas

Links in the pathway map

Supports PDCD4 inhibits mTORC2

Cite this paper

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Wang, Q., Xin, Y., Zokaei, E., Zeng, L., Piecoro, D., Chen, M., Zhang, Y., Yang, K. S., Wang, C., Liu, X., & Yang, H. S. (2026). Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC. Neoplasia. https://doi.org/10.1016/j.neo.2026.101354

@article{WANG2026B,
  author       = {Wang, Q. and Xin, Y. and Zokaei, E. and Zeng, L. and Piecoro, D. and Chen, M. and Zhang, Y. and Yang, K. S. and Wang, C. and Liu, X. and Yang, H. S.},
  title        = {{Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC}},
  journal      = {Neoplasia},
  year         = {2026},
  doi          = {10.1016/j.neo.2026.101354},
  note         = {PMID: 42648032},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WANG2026B) [Data set]. https://mtor-atlas.org/study/WANG2026B/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WANG2026B,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WANG2026B},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WANG2026B/},
  doi          = {10.5281/zenodo.22059963}
}

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