Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC.

Wang Q, Xin Y, Zokaei E et al. · 2026 · Neoplasia · Atlas ID WANG2026B

What this study shows

Pdcd4 binds Rictor via residues R105/K108/R110 to disrupt mTORC2 assembly and kinase activity, lowering PFKFB3 levels and suppressing glycolysis and NSCLC tumour growth.

Abstract

ShowHide

Programmed cell death 4 (Pdcd4) is a tumour suppressor and inhibitor of protein translation with emerging translation-independent functions. Pdcd4 suppresses tumorigenesis by disrupting mTORC2 complex formation through binding Rictor. Deletion mapping and site-directed mutagenesis defined the Rictor-binding domain of Pdcd4 and identified residues R105, K108 and R110 as critical. Co-immunoprecipitation and in vitro kinase assays showed that Pdcd4 binding to Rictor disrupted mTORC2 assembly and inhibited its kinase activity.

Read the full abstract →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: NSCLC cell lines; mouse xenograft; human tumour tissue) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	NSCLC cell lines; mouse xenograft; human tumour tissue
Journal	Neoplasia
Year	2026
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1016/j.neo.2026.101354

Extracted findings

Intervention	Pdcd4 overexpression / knockdown; Rictor-binding-deficient mutants
Target	Rictor; mTORC2; PFKFB3
Model	Human cell lines; mouse xenograft
Effect	Disrupted mTORC2 assembly and kinase activity, degraded PFKFB3, suppressed glycolysis and tumour growth

Cite this paper

ShowHide

Wang, Q., et al. (2026). Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC. Neoplasia. https://doi.org/10.1016/j.neo.2026.101354

@article{WANG2026B,
  author       = {Wang, Q. and Xin, Y. and Zokaei, E. and others},
  title        = {{Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC}},
  journal      = {Neoplasia},
  year         = {2026},
  doi          = {10.1016/j.neo.2026.101354},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WANG2026B) [Data set]. https://mtor-atlas.org/study/WANG2026B/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WANG2026B,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WANG2026B},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WANG2026B/},
  doi          = {10.5281/zenodo.22059963}
}