Oliver's mTOR Atlas Evidence Platform
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TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway.

Zhou N, Song L, Wu Y et al. · 2026 · Journal of Molecular Histology · Atlas ID ZHOU2026

What this study shows

TET1 demethylates the MRPS17 promoter to drive MRPS17 overexpression in lung adenocarcinoma, activating PI3K-AKT-mTOR signalling and increasing proliferation, migration and invasion. MRPS17 knockdown induces apoptosis and suppresses tumour growth in vitro and in vivo.

Abstract

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Lung adenocarcinoma (LUAD) poses significant therapeutic challenges. This study investigates the role of mitochondrial ribosomal protein S17 (MRPS17) in LUAD progression, focusing on its interaction with the PI3K-AKT-mTOR signaling pathway. MRPS17 is upregulated in LUAD tissues and associated with poor prognosis. MRPS17 overexpression promoted proliferation, migration and invasion, whereas knockdown induced apoptosis and diminished tumorigenic capability in vitro and in vivo.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Human LUAD cell lines; mouse xenograft) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemHuman LUAD cell lines; mouse xenograft
JournalJournal of Molecular Histology
Year2026
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1007/s10735-026-10862-8 · PMID 42665721 · Free full text (PMC13525032)

Extracted findings

InterventionMRPS17 overexpression / knockdown; TET1 modulation
TargetMRPS17; TET1; PI3K-AKT-mTOR
ModelHuman cell lines; mouse xenograft
EffectMRPS17 upregulation activates PI3K-AKT-mTOR and increases tumour aggressiveness; knockdown induces apoptosis and reduces tumour growth

Cite this paper

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Zhou, N., et al. (2026). TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway. Journal of Molecular Histology. https://doi.org/10.1007/s10735-026-10862-8

@article{ZHOU2026,
  author       = {Zhou, N. and Song, L. and Wu, Y. and others},
  title        = {{TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway}},
  journal      = {Journal of Molecular Histology},
  year         = {2026},
  doi          = {10.1007/s10735-026-10862-8},
  note         = {PMID: 42665721},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record ZHOU2026) [Data set]. https://mtor-atlas.org/study/ZHOU2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ZHOU2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ZHOU2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ZHOU2026/},
  doi          = {10.5281/zenodo.22059963}
}