TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway.

Zhou N, Song L, Wu Y, Wei Y, Zhang W, Wang B, Zhao Y, Wang Y · 2026 · Journal of Molecular Histology · Atlas ID ZHOU2026

What this study shows

TET1 demethylates the MRPS17 promoter to drive MRPS17 overexpression in lung adenocarcinoma, activating PI3K-AKT-mTOR signalling and increasing proliferation, migration and invasion. MRPS17 knockdown induces apoptosis and suppresses tumour growth in vitro and in vivo.

Abstract

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Lung adenocarcinoma (LUAD) poses significant therapeutic challenges. This study investigates the role of mitochondrial ribosomal protein S17 (MRPS17) in LUAD progression, focusing on its interaction with the PI3K-AKT-mTOR signaling pathway. MRPS17 is upregulated in LUAD tissues and associated with poor prognosis. MRPS17 overexpression promoted proliferation, migration and invasion, whereas knockdown induced apoptosis and diminished tumorigenic capability in vitro and in vivo.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Human LUAD cell lines; mouse xenograft) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Human LUAD cell lines; mouse xenograft
Journal	Journal of Molecular Histology
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1007/s10735-026-10862-8 · PMID 42665721 · Free full text (PMC13525032)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	MRPS17 overexpression / knockdown; TET1 modulation
Target	MRPS17; TET1; PI3K-AKT-mTOR
Model	Human cell lines; mouse xenograft
Effect	MRPS17 upregulation activates PI3K-AKT-mTOR and increases tumour aggressiveness; knockdown induces apoptosis and reduces tumour growth

In the Atlas

Cite this paper

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Zhou, N., Song, L., Wu, Y., Wei, Y., Zhang, W., Wang, B., Zhao, Y., & Wang, Y. (2026). TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway. Journal of Molecular Histology. https://doi.org/10.1007/s10735-026-10862-8

@article{ZHOU2026,
  author       = {Zhou, N. and Song, L. and Wu, Y. and Wei, Y. and Zhang, W. and Wang, B. and Zhao, Y. and Wang, Y.},
  title        = {{TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway}},
  journal      = {Journal of Molecular Histology},
  year         = {2026},
  doi          = {10.1007/s10735-026-10862-8},
  note         = {PMID: 42665721},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ZHOU2026) [Data set]. https://mtor-atlas.org/study/ZHOU2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ZHOU2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ZHOU2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ZHOU2026/},
  doi          = {10.5281/zenodo.22059963}
}

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