Pathway link PDCD4-MTORC2

PDCD4 ⊣ mTORC2

PDCD4 inhibits mTORC2.

PDCD4 grabs Rictor and keeps mTORC2 from working.

PDCD4 binds the mTORC2 subunit Rictor through three basic residues, which stops mTORC2 from assembling properly and lowers its kinase activity.

The conditions it holds under

Human NSCLC cell lines and mouse xenografts; not shown in normal tissue. Single study.

Time it takes

minutes

Step

direct (one molecule acts on the other)

Measured in

human cells, mouse

Where in the cell

cytosol

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“Inhibits” describes the effect on the target's activity, not on how much of it there is.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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