{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "PDCD4-MTORC2",
  "claim": "PDCD4 inhibits mTORC2",
  "source": {
   "name": "PDCD4",
   "entity": "pdcd4"
  },
  "target": {
   "name": "mTORC2",
   "entity": "mtorc2"
  },
  "effect": "inhibits",
  "type": "complex-assembly",
  "directness": "direct",
  "timescale": "minutes",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "human cells",
   "mouse"
  ],
  "mechanism": "PDCD4 binds the mTORC2 subunit Rictor through three basic residues, which stops mTORC2 from assembling properly and lowers its kinase activity.",
  "mechanism_beginner": "PDCD4 grabs Rictor and keeps mTORC2 from working.",
  "context": null,
  "boundary": "Human NSCLC cell lines and mouse xenografts; not shown in normal tissue. Single study.",
  "note": "2026-10-10: Interaction type complex-disassembly -> complex-assembly. WANG2026B: PDCD4 binding to Rictor 'disrupted mTORC2 complex assembly'; it prevents formation rather than taking apart existing complexes. Same convention as RAPA-MTORC2 (audit A10). Sign stays 'inhibits'.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "WANG2026B"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/PDCD4-MTORC2/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/PDCD4-MTORC2.json"
 }
}