Review of the molecular mechanisms of mTOR-mediated translational control.
| Evidence tier | D Mechanistic / in vitro / review |
| Study type | Narrative Review |
| Model system | Review |
| Journal | Nature reviews. Molecular cell biology |
| Year | 2009 |
| Peer reviewed | Yes |
| Source | DOI 10.1038/nrm2672 · PMID 19339977 |
The process of translation requires substantial cellular resources. Cells have therefore evolved complex mechanisms to control overall protein synthesis as well as the translation of specific mRNAs that are crucial for cell growth and proliferation. At the heart of this process is the mammalian target of rapamycin (mTOR) signalling pathway, which senses and responds to nutrient availability, energy sufficiency, stress, hormones and mitogens to modulate protein synthesis. Here, we highlight recent findings on the regulators and effectors of mTOR and discuss specific cases that serve as paradigms for the different modes of mTOR regulation and its control of translation.
| Intervention | Not applicable (review) |
| Target | mTOR / 4E-BP / S6K translation machinery |
| Model | Review |
| Effect | Reviews how mTOR senses nutrients/energy/hormones to control protein synthesis |