Molecular mechanisms of mTOR-mediated translational control

Ma XM, Blenis J · 2009 · Nature reviews. Molecular cell biology · Atlas ID MAX2009

What this study shows

Review of the molecular mechanisms of mTOR-mediated translational control.

Abstract

ShowHide

The process of translation requires substantial cellular resources. Cells have therefore evolved complex mechanisms to control overall protein synthesis as well as the translation of specific mRNAs that are crucial for cell growth and proliferation. At the heart of this process is the mammalian target of rapamycin (mTOR) signalling pathway, which senses and responds to nutrient availability, energy sufficiency, stress, hormones and mitogens to modulate protein synthesis.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Nature reviews. Molecular cell biology
Year	2009
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/nrm2672 · PMID 19339977

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTOR / 4E-BP / S6K translation machinery
Model	Review
Effect	Reviews how mTOR senses nutrients/energy/hormones to control protein synthesis

In the Atlas

Links in the pathway map

Supports 4E-BP1 inhibits eIF4E
Supports eIF4E activates Protein synthesis

Cite this paper

ShowHide

Ma, X. M., & Blenis, J. (2009). Molecular mechanisms of mTOR-mediated translational control. Nature reviews. Molecular cell biology. https://doi.org/10.1038/nrm2672

@article{MAX2009,
  author       = {Ma, X. M. and Blenis, J.},
  title        = {{Molecular mechanisms of mTOR-mediated translational control}},
  journal      = {Nature reviews. Molecular cell biology},
  year         = {2009},
  doi          = {10.1038/nrm2672},
  note         = {PMID: 19339977},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MAX2009) [Data set]. https://mtor-atlas.org/study/MAX2009/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MAX2009,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MAX2009},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MAX2009/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?