Pathway link EIF4E-TRANSL
eIF4E Protein synthesis
eIF4E activates Protein synthesis.
Freed eIF4E brings the ribosome to the mRNA – the step that actually turns a growth signal into new protein.
The conditions it holds under
Biochemical and cell-based evidence (mouse cells with ribosome profiling, mouse models with human prostate cancer data in one study) plus a review. How much a given tissue depends on eIF4E-driven translation is not settled by these sources.
- Time it takes
- minutes
- Step
- direct (one molecule acts on the other)
- Measured in
- mammalian cells
- Where in the cell
- cytosol
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2009 | R | Molecular mechanisms of mTOR-mediated translational controlMAX2009 Review of the molecular mechanisms of mTOR-mediated translational control. |
| 2012 | M | The translational landscape of mTOR signalling steers cancer initiation and metastasisHSI2012 Showed WHY mTOR-driven translation matters for cancer: in prostate cancer, oncogenic mTOR selectively translates a specific set of pro-invasion mRNAs that drive metastasis. An ATP-competitive mTOR inhibitor (INK128) reversed that signature - an early preclinical rationale from mouse models and cell lines, not a clinical result. |
| 2012 | M | A unifying model for mTORC1-mediated regulation of mRNA translationTHO2012 Used ribosome profiling with the complete inhibitor Torin1 to address a long-standing debate: in these cells, mTORC1's translational control runs largely through the 4E-BP family acting on a specific class of mRNAs (TOP motifs). Losing just the 4E-BPs makes translation of TOP mRNAs resistant to mTOR inhibition - naming them the master effectors. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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